The study supports the notion that neuropsychological assessment for AD needs to abandon the notion of one-size-fits-all. Their complementary value was high during the mid-prodromal stages and decreased in stages closer to dementia. As the disease progressed, the FCSRT became a strong predictor excluding the VSTMB from the models. Only the VSTMBT predicted group membership in the very early stages (HOA vs eMCI). Using baseline and follow-up assessments four groups were defined: Older adults who were healthy (HOA), with very mild cognitive but not functional impairment (eMCI), and with MCI who did and did not convert to dementia (MCI converters and non-converters). Participants with at least two assessment points entered the study. Healthy older adults (n=70) and patients with mild cognitive impairment (MCI) (n=80) were recruited and followed up between 20. It was hypothesised that the VSTMBT would be an early indicator while the FCSRT would inform on imminent progression. The individual and complementary value of the Visual Short-Term Memory Binding Test (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) as markers to trace the AD continuum was investigated.
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